Single Use Upstream Bioprocessing Markets (Bioreactors, Media Bags, Bioprocess Containers, Tubing and Connectors, Mixing Systems, Sensors and Probes)

4 May 2018

Categories:

Biopharmaceuticals Biotechnology Biopharmaceuticals Laboratory Diagnostics Life Science & Instruments Kalorama Information

This report analyzes the current and potential world market for single use systems for upstream bioprocessing.

Table of Contents

1: Executive Summary
- Overview
- Methodology
- Market Overview
2: Introduction
- Upstream Bioprocessing Perspective
  - Bioreactors
  - Single Use Bioreactors
  - Other Single Use Products
- Traditional Processing
- Disposable Processing
  - Methodical Progress
  - Components and Regulation
  - Some Impediments
  - But Biosimilar and Biologics Opportunities
- Variations in Bioreactor Types
  - Stainless Steel
  - Stirred-Tank Reactors
  - Airlift Fermenters
  - Packed Bed Reactors
  - Hollow-Fiber Reactors
  - Single Use Systems
- Flexibility
  - Vaccine Manufacture
  - Product Variety
- But Challenges Loom
  - Alternating Scales
  - Automation
  - Compliance
  - Distribution
  - Integrity
- Yet Opportunities in Targeted Therapeutics
  - Newer Protein Therapies
  - Cell-Culture-Based Technology
  - Cost-Effective Solution
  - Outsourcing Continues
  - Capacity Investment Shifting
3: Single Use Bioprocessing Trends
- Robust Expansion
- Product Titer Growth
- Perfusion
  - Intensified Perfusion
- Retrofitting Facilities
- Flexibility
- Cell Retention and Capacity
- Reducing Utility Costs
- Modular Facilities
- Local Production
4: Issues Facing Single Use Bioprocessing
- Single Use or Stainless
- Some Costs Involved
- Vendor Auditing
- Regulatory Challenges
  - Leaching
- Qualifying Vendors
  - Plastic Purity
- Customization
- Standardization
5: Market Developments
- 4,000 Liter Single-Use Bioreactor Installed
- Disposable Mixing Systems
- Smart Sensors
- Non-GMP Pilot Plant
- Continuous Bioprocess Laboratory
- Disposable Technologies for Scale Up
- Maximizing Efficiency – Customization
- Single Use Storage Containers
- Single Use Specialist
- Driving Single Use
- New Test Center
- New Modular Facility System
- Single Use for Cell Therapy
6: Market Landscape
- Early Penetration
- Niche Opportunities
- Integral to Bioprocessing
- Demand from Local Markets
- Market Disruption
- Beyond the Small Scale
- Different Manufacturing Options Possible
- Opportunities for Suppliers
- Smaller Targeted Markets
- Markets in Transition
  - Diversity
  - Continuous Flow Processing
  - More Responsive Supply Chain
  - Drivers
7: Market Analysis and Forecasts
- Wide Acceptance Worldwide
  - Emerging Markets
- Stainless Steel Still Competitive
- Single Use Bioreactors
- Single Use Media Bags
- Single Use Bioprocess Containers
- Single Use Tubing and Connectors
- Single Use Mixing Systems
- Single Use Sensors and Probes
  - Single Use Pressure Sensors and Probes
  - Single Use Temperature Sensors and Probes
  - Single Use pH Sensors and Probes
  - Single Use Dissolved Oxygen Sensors and Probes
8: Corporate Profiles
- Abec, Bethlehem, PA 18017, www.abec.com
- Applikon Biotechnology, Delft, Netherlands, www.applikon-bio.com
- Broadley-James Corp., Irvine, CA 92618, www.broadleyjames.com
- Cellexus, Dundee, UK, www.cellexus.com
- Cellon SA, Grand Duché du Luxembourg, www.cellon.lu
- Celltainer Biotech BV, Winterswijk Brinkheurne, The Netherlands, www.celltainer.com
- CerCell ApS, Holte Denmark, www.cercell.com
- CPC (Colder Products Company), St. Paul, MN 55114, www.cpcworldwide.com
- Cronus-PCS, DK-2840 Holte, Denmark, www.cronus-pcs.com
- EireChrom, Mahon, Co. Cork, T12 W7CV Ireland, www.eirechrom.ie
- Eppendorf, Hamburg, Germany, www.eppendorf.com/US-en/
- ESI Ultrapure, Cwmbran, Torfaen, NP44 3XS, UK, www.esitechgroup.com
- Finesse Solutions, Santa Clara, CA 95054, www.finesse.com
- GE Healthcare’s Life Sciences Business, Pittsburgh, PA 15264, www.gelifesciences.com/webapp/wcs/stores/servlet/catalog/en/GELifeSciences-us/brands/xcellerex
- Hamilton Robotics, Bonaduz, Switzerland, www.hamiltoncompany.com
- Holland Applied Technologies, Burr Ridge, IL 60527, http://www.hollandapt.com
- Millipore, Millipore Sigma, Burlington, MA 01803, www.emdmillipore.com
- NewAge Industries, Southampton, PA 18966, www.newageindustries.com
- Pall Biotech, Port Washington, NY 11050, https://biotech.pall.com
- Parker Hannifin, Cleveland, OH 44124, www.parker.com
- PBS Biotech, Camarillo, CA 93012, www.pbsbiotech.com
- PendoTech, Princeton, NJ 08542, www.pendotech.com
- PerfuseCell A/S, DK-2840 Holte, Denmark, www.perfusecell.com
- PreSens Precision Sensing, 93053 Regensburg, Germany, www.presens.de
- ProlifeCell, DK-2840 Holte, Denmark, www.prolifecell.com/product
- PumpCell A/S, DK-2840 Holte, Denmark, www.pumpcell.com
- Refine Technology, Pine Brook, NJ 07058, www.refinetech.com
- Sartorius AG, Goettingen, Germany, www.sartorius.com
- Stobbe Tech, DK-2840 Holte, Denmark, www.stobbe.com/research/biotech/glycocell
- Sysbiotech, Perigny France, www.sysbiotech.eu
- Thermo Fisher Scientific, Waltham, MA 02451, www.thermofisher.com/us/en/home/life-science/bioproduction/single-use-bioprocessing.html
- Zeta Holding, Graz, Austria, www.zeta.com